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Symbol
Name
ID

Six3
sine oculis-related homeobox 3
MGI:102764

Phenotype annotations related to nervous system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Dandy-Walker malformation

Microcephaly

Encephalocele

Anosmia

Hyposmia

Anterior pituitary agenesis

Anterior hypopituitarism

Panhypopituitarism

Spasticity

Abnormal nervous system morphology

Hydrocephalus

Aplasia/Hypoplasia of the corpus callosum

Agenesis of corpus callosum

Aplasia/Hypoplasia of the cerebellum

Cerebellar hypoplasia

Holoprosencephaly

Alobar holoprosencephaly

Semilobar holoprosencephaly

Spinal dysraphism

Spinal cord tumor

Abnormality of neuronal migration

Chorea

Cognitive impairment

Intellectual disability

Dystonia

Global developmental delay

Seizure

Disease(s) Associated with SIX3

holoprosencephaly

holoprosencephaly 2

Mouse Phenotypes		abnormal neural tube morphology	abnormal forebrain development	absent embryonic telencephalon	holoprosencephaly	decreased forebrain size	increased midbrain size
Availability	Mouse Genotype	abnormal neural tube morphology	abnormal forebrain development	absent embryonic telencephalon	holoprosencephaly	decreased forebrain size	increased midbrain size
	Six3^tm1Gco/Six3^tm1Gco
	Six3^tm2.1Gco/Six3^tm2.1Gco
	Six3^{tm4(cre/ERT2)Gco}/Six3⁺				!
	Six3^tm3Gco/Six3^tm3Gco Foxg1^tm1(cre)Skm/Foxg1⁺ (conditional)
	Six3^tm2Gco/Six3^tm2.1Gco Tg(Pax6-cre,GFP)1Pgr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23